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Pharmacology of St. John's Wort

The following are compounds found in St. John's wort:

  • Anthracene derivatives (0.1 - 0.15%): favoring naphthadihydrodianthrones, in particular hypericin, pseudohypericin.
  • Flavonoids (2-4%): such as hyperoside, quercitrin, rutin, and isquercitrin.
  • Bioflavonoids including among others - amentoflavone.
  • Xanthones: 1,3,6,7-tetrahydroxy-xanthone
  • Acylphloroglucinols: hyperforin with small quantities of adhhyperforin.
  • Volatile Oil: chief components aliphatic hydrocarbons, including 2-mthyloctane, undecane, dodecanol, caryophyllene and 2-methyl-3-but-3-en-2-ol.
  • Oligomeric procyanidines
  • Catechin tannins
  • Caffeic acid derivatives: including cholorogenic acid.
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